Publikacje

1.    Łazarczyk Marzena, Mickael Michel Edwar, Skiba Dominik, Kurzejamska Ewa, Ławiński Michał, Horbańczuk Jarosław Olav, Radziszewski Jakub, Frączek Karolina, Wolińska Renata, Paszkiewicz Justyna, Religa Piotr, Sacharczuk Mariusz. The Journey of Cancer Cells to the Brain: Challenges and Opportunities. International Journal of Molecular Sciences. 2023; 24. 
2.    Ordak M, Libman-Sokolowska M, Nasierowski T, Badyra B, Kaczmarek L, Muszynska E, Bujalska-Zadrozny M. Matrix metalloproteinase-3 serum levels in schizophrenic patients. International Journal of Psychiatry in Clinical Practice. 2023; 27.    
3.    Ordak M. How can we Talk About Breakthroughs if the Quality of Statistical Analyses Leaves Much to be Desired?    Archives of Medical Research. 2023;    S0188-4409(23)00054-1.
4.    Ordak M. Current research in translational medicine - biostatistical recommendations for authors. Current Reseach in Translational Medicine. 2023; 71. 
5.    Ordak M. Multiple comparisons and effect size: Statistical recommendations for authors planning to submit an article to Allergy. Allergy. 2023; 75. 
6.    Ordak M. Precision medicine in oncology - machine learning recommendations. American Journal of Cancer Research. 2023; 13. 
7.    Golub A, Ordak M, Nasierowski T, Bujalska-Zadrozny M. Reasons, Form of Ingestion and Side Effects Associated with Consumption of Amanita muscaria.    Toxics. 2023; 11. 
8.    M.Pasierski, W. Kołba, B.Szulczyk. Guanfacine inhibits interictal epileptiform events and sodium currents in prefrontal cortex pyramidal neurons. Pharmacological Reports. 2023;    75.
9.    Madruga-Rimoli CC, Sanfins MD, Skarżyński PH, Ubiali T, Skarżyńska MB, Colella Dos Santos MF. Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Students Aged Between 8 and 12 years. Medical Science Monitor. 2023; 29.
10.    Sanfins MD, Gielow I, Madazio G, Honorio F, Bordin T, Skarżyński PH, Skarżyńska MB, Behlau M.    The Effects of Monaural Stimulation on Frequency-Following Responses in Adults Who Can Sing in Tune and Those Who Cannot. International Archives of Otorhinolaryngology. 2023; 8. 
11.    Lazarczyk M, Duda K, Mickael ME, Ak O, Paszkiewicz J, Kowalczyk A, Horbańczuk JO, Sacharczuk M. Adera2.0: A Drug Repurposing Workflow for Neuroimmunological Investigations Using Neural Networks. Molecules. 2022; 27. 
12.    M. Abram i wsp. Discovery of (R)‑N‑Benzyl-2-(2,5-dioxopyrrolidin-1-yl)propanamide [(R)-AS‑1], a Novel Orally Bioavailable EAAT2 Modulator with Druglike Properties and Potent Antiseizure Activity In Vivo. Journal of Medicinal Chemistry. 2022; 65.     
13.    Lach P, Klus W, Zajdel K, Szeleszczuk A, Komorowska E, Burda K, Kurowski P. Neuroinflammantion in epilepsy - diagnostics and therapeutic perspectives. Current Pharmacology Reports. 2022. 8; 31. 
14.    M.Pasierski, B.Szulczyk. Beneficial Effects of Capsaicin in Disorders of the Central Nervous System. Molecules. 2022; 27.     
15.    B.Szulczyk, M.Pasierski, M.Gawlak. Prefrontal cortex pyramidal neurons express functional Nav1.8 tetrodotoxin-resistant sodium currents. Clinical and Experimental Pharmacology and Physiology. 2022; 49.     
16.    A.Spyrka, B.Szulczyk. Menthol exerts TRPM8-independent antiepileptic effects in prefrontal cortex pyramidal neurons. Brain Research. 2022; 1783. 
17.    M.Jakubiec i wsp. New Phenylglycinamide Derivatives with Hybrid Structure as Candidates for New Broad-Spectrum Anticonvulsants. Cells. 2022; 11.     
18.    Skarżyńska MB, Książek A, Szum A, Tkacz D, Skarżyński PH.    Praktyczne aspekty stosowania różnych grup farmakologicznych substancji czynnych w otorynolaryngologii i audiologii oraz analiza możliwości i ryzyka wystąpienia istotnych klinicznie interakcji tych leków z innymi, z wyłączeniem leków stosowanych w chemioterapii nowotworów głowy i szyi. Nowa Audiofonolofia. 2022; 11. 
19.    Ordak M, Sloniewicz N, Nasierowski T, Muszynska E, Bujalska-Zadrozny M. Manganese concentration in patients with encephalopathy following ephedrone use: a narrative review and analysis of case reports. Clinical Toxicology. 2022; 60.
20.    Ponikowska D., Dworakowska A., Czepielewska E., Kozłowska-Wojciechowska M.     Subjective evaluation of the effectiveness of treatment of chronic obstructive pulmonary disease – a qualitative study (Warsaw, Poland). Archives of Medical Science - Civilization Diseases. 2022; 7.
21.    Lisowska A., Czepielewska E., Rydz M., Dworakowska A., Makarewicz-Wujec M., Kozłowska-Wojciechowska M.  Applicability of tools to identify potentially inappropriate prescribing in elderly during medication review: Comparison of STOPP/START version 2, Beers 2019, EU(7)-PIM list, PRISCUS list, and Amsterdam tool—A pilot study. PLoS One    . 2022; 17.     
22.    Oberska J., Dworakowska A., Kozłowska-Wojciechowska M. Opinions of pharmacists in Poland on changes in professional competencies due to the COVID-19 pandemic. Acta Poloniae Pharmaceutica - Drug Research. 2022; 79.                         
23.    Bankiewicz P., Dworakowska A., Makarewicz-Wujec M., Kozłowska-Wojciechowska M.  Beliefs and sentiments of parents vaccinating their children - small town perspective in Poland: a preliminary study. Central European Journal of Public Health. 2022; 30. 
24.    Janeczek K, Emeryk A, Zimmer Ł, Poleszak E, Ordak M. Nasal carriage of Staphylococcus aureus in children with grass pollen-induced allergic rhinitis and the effect of polyvalent mechanical bacterial lysate immunostimulation on carriage status: A randomized controlled tria. Immunity, Inflammation and Disease    . 2022;    10.
25.    Ordak M, Tkacz D, Golub A, Nasierowski T, Bujalska-Zadrozny M.     Polypharmacotherapy in Psychiatry: Global Insights from a Rapid Online Survey of Psychiatrists. Journal of Clinical Medicine. 2022; 11. 
26.    Ordak M. Biostatistics in allergy - recommendations for authors. Allergy. 2022; 77.     
27.    Ordak M. Recommendations to medical journals on ways to encourage statistical experts to review submissions. Current Medical Research and Opinion. 2022; 38.
28.    Kulik K, Żyżyńska-Granica B, Kowalczyk A, Kurowski P, Gajewska M, Bujalska-Zadrożny M. Magnesium and Morphine in the Treatment of Chronic Neuropathic Pain–A Biomedical Mechanism of Action. International Journal of Molecular Sciences. 2021; 22.     
29.    Dworakowska B, Gawlak M, Nurowska E. Activity of TREK-2-Like Channels in the Pyramidal Neurons of Rat Medial Prefrontal Cortex Depends on Cytoplasmic Calcium. Biology. 2021; 10.
30.    Bochon K, Zielniok K, Gawlak M, Zawada  K, Zarychta-Wiśniewska  W, Siennicka K, Struzik, S, Pączek L, Burdzińska A.  The Effect of L-Ascorbic Acid and Serum Reduction on Tenogenic Differentiation of Human Mesenchymal Stromal Cells. International Journal of Stem Cells. 2021; 14.
31.    M.Abram i wsp. Asymmetric synthesis and in vivo/in vitro characterization of new hybrid anticonvulsants derived from (2,5-dioxopyrrolidin-1-yl)phenylacetamides. Bioorganic Chemistry. 2021. 109; 5. 
32.    M.Abram i wsp. Identification of New Compounds with Anticonvulsant and Antinociceptive Properties in a Group of 3-substituted (2,5-dioxo-pyrrolidin-1-yl)(phenyl)-Acetamides. International Journal of Molecular Sciences. 2021; 22.     
33.    Frączek K, Kowalczyk A, Pękala M, Kasarełło K, Sygitowicz G, Sulejczak D, Zaremba M, Konop M, Frankowska M, Filip M, Bujalska-Zadrożny M, Kleczkowska P. The Positive and Negative Outcome of Morphine and Disulfiram Subacute Co-Administration in Rats in the Absence of Ethanol Challenge. Pharmaceutics. 2021;    13.     
34.    Kołtowski Ł, Średniawa B, Tycińska A, Czajkowska M, Niedziela M, Puchalski W, Szczerba E, Kowalik R, Ryczek R, Zawiślak B, Kremis E, Koza K, Nazaruk A, Wolska J, Ordak M, Opolski G, Stępińska J. Predicting survival in out-of-hospital cardiac arrest patients undergoing targeted temperature management: The Polish Hypothermia Registry Risk Score. Cardiology Journal. 2021; 28.
35.     Dworakowska A., Czepielewska E., Andrulonis N., Lisowska A., Kozłowska-Wojciechowska M. Intentional non-adherence to medications in the elderly – results from a pilot study (Warsaw, Poland). Acta Poloniae Pharmaceutica - Drug Research. 2021; 78.             
36.    Merks P., Religioni U., Bilmin K., Lewicki J., Jakubowska M., Waksmundzka-Walczuk A. et al. Readiness and Willingness to Provide Immunization Services after Pilot Vaccination Training: A Survey among Community Pharmacists Trained and Not Trained in Immunization during the COVID-19 Pandemic in Poland. Int J Environ Res Public Health. 2021; 18.    
37.    Pytko-Polonczyk J, Soltys-Kozicka K, Stawarz-Janeczek M, Krakowska A, Ordak M, Kryczyk-Poprawa A, Podkowa A, Muszynska B, Opoka W. Determination of the effect of selected diseases on the level of zinc and magnesium in teeth extracted from patients for clinical reasons. Journal of Physiology and Pharmacology. 2021;    72. 
38.    Ordak M, Zmysłowska A, Bielski M, Rybak D, Tomaszewska M, Wyszomierska K, Kmiec A, Garlicka N, Zalewska M, Zalewski M, Nasierowski T, Muszynska E, Bujalska-Zadrozny M. Pharmacotherapy of Patients Taking New Psychoactive Substances: A Systematic Review and Analysis of Case Reports. Frontiers in Psychiatry. 2021; 12. 
39.    Wolińska Renata, Kleczkowska Patrycja, De Cordé-Skurska Anna, Poznański Piotr, Sacharczuk Mariusz, Mika Joanna, Bujalska-Zadrożny Magdalena. Nitric oxide modulates tapentadol antinociceptive tolerance and physical dependence. European Journal of Pharmacology. 2021; 907.
40.    Mieczkowski Mateusz, Mrozikiewicz-Rakowska Beata, Siwko Tomasz, Bujalska-Zadrożny Magdalena Izabela, De Cordé-Skurska Anna Elżbieta, Wolińska Renata, Gąsińska Emilia, Grzela Tomasz, Foltyński Piotr, Kowara Michał, Mieczkowska Zofia, Czupryniak Leszek. Insulin, but Not Metformin, Supports Wound Healing Process in Rats with Streptozotocin-Induced Diabetes. Diabetes Metabolic Syndrome and Obesity-Targets and Therapy. 2021; 14.         
41.    Agata, Poznański Piotr, Łazarczyk Marzena, Gorzałczyński Michał, Skiba Dominik, Wolińska Renata, Bujalska-Zadrożny Magdalena Izabela, Lutfy Kabirullah, Sadowski Bogdan, Sacharczuk Mariusz. The Influence of Cross-Fostering on Alcohol Consumption and Depressive-Like Behaviors in HA and LA Mice: The Role of the Endogenous Opioid System. Brain Sciences. 2021; 11. 
42.    Ordak M, Nasierowski T, Muszynska E, Bujalska-Zadrozny M. Increasing the Effectiveness of Pharmacotherapy in Psychiatry by Using a Pharmacological Interaction Database. Journal of Clinical Medicine. 2021; 10. 
43.    Ordak M, Nasierowski T, Muszynska E, Bujalska-Zadrozny M. Psychoactive Substances Taken with Mephedrone and HCV Infection. Journal of Clinical Medicine. 2021; 10.
44.    Ordak M. COVID-19 research: quality of biostatistics. Archives of Medical Science. 2021.     18; 1. 
45.    Ordak M, Nasierowski T, Muszynska E, Bujalska-Zadrozny M. The Psychiatric Characteristics of People on a Mephedrone ("bath salts") Binge. Substance Use & Misuse. 2020; 55. 
46.    Korczak M, Kurowski P, Leśniak A, Grönbladh A, Filipowska A, Bujalska-Zadrożny M. GABAB receptor intracellular signaling: novel pathways for depressive disorder treatment? 2020. European Journal of Pharmacology. 173531. 
47.    Milena Czajka , Agnieszka Zajkowska , Maciej Gawlak ,  Magdalena Bujalska-Zadrożny,  Maciej  Małecki. Mosaic Recombinant Adeno-associated Virus Vector rAAV/DJ/CAG for Targeted Gene Delivery to Melanoma Cells Metastasized to the Lung. Anticancer Research. 2020; 40.
48.     K.Kamiński i wsp. N-Benzyl-(2,5-dioxopyrrolidin-1-yl)propanamide (AS-1) with Hybrid Structure as a Candidate for a Broad-Spectrum. Antiepileptic Drug    Neurotherapeutics. 2020. 17; 1.     
49.    M.Pasierski, SzulczykB. Capsaicin inhibits sodium currents and epileptiform activity in prefrontal cortex pyramidal neurons. Neurochemistry International. 2020. 135.
50.    M.Dawidowski i wsp.    Structure-activity relationship and cardiac safety of 2-aryl-2-(pyridin-2-yl)acetamides as a new class of broad-spectrum anticonvulsants derived from Disopyramide. Bioorganic Chemistry. 2020; 98.         
51.    K.Kamiński i wsp. KA-104, a new multitargeted anticonvulsant with potent antinociceptive activity in preclinical models. Epilepsia. 2020; 61. 
52.    Frączek K, Ferraiolo M, Hermans E, Bujalska-Zadrożny M, Kasarełło K, Erdei A, Kulik K., Kowalczyk A, Wojciechowski P, Sulejczak D, Sosnowski P, Granica S, Benyhe S, Kaczynska K, Nagraba Ł, Stolarczyk A, Cudnoch-Jędrzejewska A, Kleczkowska P.     Novel opioid-neurotensin-based hybrid peptide with spinal long-lasting antinociceptive activity and a propensity to delay tolerance development. Acta Pharmaceutica Sinica B. 2020; 10.     
53.    Ordak M, Nasierowski T, Muszynska E, Bujalska-Zadrozny M.  Optimisation of methadone treatment in a group of patients on a mephedrone binge and dependent on many psychoactive substances. International Journal of Psychiatry in Clinical Practice. 2020    ; 24. 
54.    Dworakowska A., Zawada M., Kozłowska-Wojciechowska M. The self-management experience of subjects with hypertension - results from a qualitative study (Warsaw, Poland). Acta Poloniae Pharmaceutica - Drug Research. 2020; 77.    4    
55.    Lisowska A., Dworakowska A., Serafin A., Kozłowska-Wojciechowska M. ‘If i knew that it could help…’ – factors influencing adherence to treatment after myocardial infarction – results from a qualitative study guided by health belief model. Acta Poloniae Pharmaceutica - Drug Research. 2020; 77.                 
56.    Ordak M, Nasierowski T, Pawlik K, Muszynska E, Bujalska-Zadrozny M. Effectiveness of the methadone programme in the treatment of patients on a mephedrone binge and dependent on heroin: a retrospective study, 2010-19. International Journal of Psychiatry in Clinical Practice. 2020; 24. 
57.     Dworakowska A., Aniszewska A., Kozłowska-Wojciechowska M. Older adults’ strategies to prevent episodic medication non-adherence: results from a qualitative study. European Geriatric Medicine. 2019; 10.         
58.     B.Szulczyk, M.Pasierski, E.Nurowska    Valproic acid potently inhibits interictal-like epileptiform activity in prefrontal cortex pyramidal neurons. Neuroscience Letters. 2019; 708.
59.    Katarzyna Grzelka , Maciej Gawlak , Katarzyna Czarzasta , Paweł Szulczyk. Effects of β3-adrenergic receptor stimulation on the resting holding current of medial prefrontal cortex pyramidal neurons in young rats. Neuroscience Letters. 2019; 698.     
60.    K.Socała i wsp.    KA-11, a Novel Pyrrolidine-2,5-dione Derived Broad-Spectrum Anticonvulsant: Its Antiepileptogenic, Antinociceptive Properties and in Vitro Characterization. ACS Chemical Neuroscience. 2019; 10.         
61.    Lisowska A., Makarewicz-Wujec M., Dworakowska A., Kozłowska-Wojciechowska M.  Adherence to guidelines for pharmacological treatment of young adults with myocardial infarction in Poland: Data from Polish Registry of Acute Coronary Syndromes (PL-ACS). Journal of Clinical Pharmacy and Therapeutics.  2019; 44.     
62.    Sławińska Kinga , Nurowska Ewa , Dworakowska Beata. TTX-resistant sodium currents in medial prefrontal cortex pyramidal neurons depend on extracellular Ca2+ concentration. Medical Research Journal. 2019.    4; 1.    
63.    Nurowska Ewa , Adamiec Milena , Dworakowska Beata. Extracellular divalent ions modulate TREK-2-like channel conductance in prefrontal pyramidal neurons in rats. Medical Research Journal. 2019. 4; 1. 
64.    Kurowski P, Grzelka K, Szulczyk P. Ionic mechanism underlying rebound depolarization in medial prefrontal cortex pyramidal neurons. Frontiers in Cellular Neuroscience. 2018. 12; 93. 
65.    Ordak M, Bulska E, Jablonka-Salach K, Luciuk A, Maj-Żurawska M, Matsumoto H, Nasierowski T, Wojnar M, Matras J, Muszynska E, Bujalska-Zadrozny M.  Effect of Disturbances of Zinc and Copper on the Physical and Mental Health Status of Patients with Alcohol Dependence. Biological Trace Element Research. 2018; 183. 
66.    Dworakowska Beata , Nurowska Ewa , Dołowy Krzysztof.    Hydrocortisone inhibition of wild-type and αD200Q nicotinic acetylcholine receptors. Chemical Biology & Drug Design. 2018. 92; 3. 
67.    Kowalczyk A, Kleczkowska P, Konop M, Kasarełło K, Czuwara J, Pękala M, Sosnowski P, Sacharczuk M, Cudnoch-Jędrzejewska A, Rudnicka L, Bujalska-Zadrożny M.  Determination of the anti-inflammatory properties and analgesic activity of the AA3052 chimeric peptide against CFA-induced inflammatory pain. Animal Science Papers and Reports. 2018; 36. 
68.     Makarewicz-Wujec M., Dworakowska A., Kozłowska-Wojciechowska M. Replacement of saturated and trans-fatty acids in the diet v. CVD risk in the light of the most recent studies. Public Health Nutrition. 2018; 21.                     
69.    Dworakowska A., Aniszewska A., Kozłowska-Wojciechowska M. Możliwości wspierania pacjenta w przestrzeganiu zaleceń terapeutycznych. Farmacja Polska.    2018; 74.     
70.    Artur Kasprzak, Ireneusz Grudziński,  Magdalena Bamburowicz-Klimkowska,  Andrzej Parzonko, Maciej Gawlak ,Magdalena Popławska . New Insight into the Synthesis and Biological Activity of the Polymeric Materials Consisting of Folic Acid and β-Cyclodextrin. Macromolecular Bioscience. 2018; 18.     
71.    Róża Chmielewska, Maciej Gawlak ,  Magdalena Bamburowicz-Klimkowska, Magdalena Popławska ,  Ireneusz Grudziński. Distribution of polyethylenimine in zebrafish embryos. Roczniki Państwowego Zakładu Higieny. 2018; 69.         
72.    Ordak M, Nasierowski T, Muszynska E. The growing problem of mephedrone use in Warsaw, Poland, 2010-18. Lancet Psychiatry. 2018; 5. 
73.    De Cordé Anna, Krząścik Paweł Tomasz, Wolińska Renata, Kleczkowska Patrycja, Filip Małgorzata, Bujalska-Zadrożny Magdalena Izabela. Disulfiram attenuates morphine or methadone withdrawal syndrome in mice. Behavioural Pharmacology. 2018. 29; 5.    
74.    Maciej Gawlak, Szulczyk  Bartłomiej,  Adam Berłowski,  Katarzyna Grzelka,  Anna Stachurska,  Justyna Pełka,  Katarzyna Czarzasta, Maciej Małecki , Przemysław Kurowski ,  Ewa Nurowska ,  Paweł  Szulczyk. Age-dependent expression of Nav1.9 channels in medial prefrontal cortex pyramidal neurons in rats. Developmental Neurobiology. 2017; 77. 
75.    Janusz Skrzypecki  , Maciej Gawlak ,  Tomasz Hutsch,  Paweł Szulczyk, Marcin Ufnal . Renal denervation decreases blood pressure and renal tyrosine hydroxylase but does not augment the effect of hypotensive drugs. Clinical and Experimental Hypertension. 2017; 39.     
76.    Kinga Jaworska,  Tomasz Hutsch,  Emilia Samborowska, Leszek Dobrowolski , Klaudia Maksymiuk  , Maciej Gawlak ,Marcin  Ufnal . Hypertension in rats is associated with an increased permeability of the colon to TMA, a gut bacteria metabolite. PLoS One. 2017; 12. 
77.    Katarzyna Grzelka , Przemysław Kurowski , Maciej Gawlak ,  Paweł Szulczyk. Noradrenaline Modulates the Membrane Potential and Holding Current of Medial Prefrontal Cortex Pyramidal Neurons via β1-Adrenergic Receptors and HCN Channels. Frontiers in Cellular Neuroscience. 2017. 11; 1. 
78.    Wioletta Ładno , Maciej Gawlak ,  Paweł Szulczyk , Ewa  Nurowska . Kinetic properties and adrenergic control of TREK-2-like channels in rat medial prefrontal cortex (mPFC) pyramidal neurons. Brain Research. 2017. 1665    ; 95.     
79.    Ordak M, Maj-Zurawska M, Matsumoto H, Bujalska-Zadrozny M, Kieres-Salomonski I, Nasierowski T, Muszynska E, Wojnar M. Ionized magnesium in plasma and erythrocytes for the assessment of low magnesium status in alcohol dependent patients. Drug and Alcohol Dependence.    2017; 178. 
80.     Bujalska-Zadrożny M, Tatarkiewicz J, Kulik K, Filip M, Naruszewicz    M. Magnesium enhances opioid-induced analgesia –What we have learnt in the past decades? European Journal of Pharmaceutical Sciences. 2017; 99. 
81.     B.Szulczyk, E.Nurowska. Valproic acid inhibits TTX-resistant sodium currents in prefrontal cortex pyramidal neurons. Biochemical and Biophysical Research Communications. 2017. 491; 2.    
82.    Ordak M, Matras J, Muszynska E, Nasierowski T, Bujalska-Zadrozny M. Magnesium in schizophrenia. Pharmacological Reports. 2017; 69. 
83.    Kleczkowska P, Kowalczyk A, Leśniak A, Bujalska-Zadrożny M. The Discovery and Development of Drug Combinations for the Treatment of Various Diseases from Patent Literature (1980-Present). Current Topics in Medicinal Chemistry. 2017;  17. 
84.    Wolińska Renata, Leśniak Anna, Żochowska Małgorzata, Sacharczuk Mariusz, Kieć-Kononowicz Katarzyna, Bujalska-Zadrożny Magdalena. Antinociceptive effect of co-administered NMDA and histamine H4 receptor antagonists in a rat model of acute pain. Pharmacological Reports    . 2017; 69. 
85.    Dworakowska A. Wywiad motywujący w praktyce aptekarza. Jak farmaceuta może wspierać pacjenta w prozdrowotnej zmianie?    Farmacja Polska. 2017; 73. 
86.    Piecuch A., Makarewicz-Wujec M., Kozłowska-Wojciechowska M. Improving the provision of OTC medication information in community pharmacies in Poland. International Journal of Clinical Pharmacy. 2017; 39.                        
87.    Piecuch A., Makarewicz-Wujec M., Kozłowska-Wojciechowska M.    Hello, Doctor! – Professional interactions with physicians according to pharmacists in Poland. Acta Poloniae Pharmaceutica - Drug Research. 2017;    74.